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11. Park, S.J.*, Yoo, H.C.*, Ahn, E., Luo, E., Kim, Y., Sung, Y., Yu, Y.C., Kim, K., Min, D.S., Lee, H.S., et al. (2023). Enhanced glutaminolysis drives hypoxia-induced chemoresistance in pancreatic cancer. Cancer Research, https://doi.org/10.1158/0008-5472.CAN-22-2045
10. Kim, K.*, Yoo, H.C.*, Kim, B.G., Kim, S., Sung, Y., Yoon, I., Yu, Y.C., Park, S.J., Kim, J.H., Myung, K., et al. (2022). O-GlcNAc modification of leucyl-tRNA synthetase 1 integrates leucine and glucose availability to regulate mTORC1 and the metabolic fate of leucine. Nature Communications 13, 2904. https://doi.org/10.1038/s41467-022-30696-8
9. Yoo, H.C., and Han, J.M. (2022). Amino Acid Metabolism in Cancer Drug Resistance. Cells 11, 140, https://doi.org/10.3390/cells11010140
8. Kim, J.H., Jung, K., Lee, C., Song, D., Kim, K., Yoo, H.C., Park, S.J., Kang, J.S., Lee, K.R., Kim, S., Han, J.M., and Han, G. (2021). Structure-based modification of pyrazolone derivatives to inhibit mTORC1 by targeting the leucyl-tRNA synthetase-RagD interaction. Bioorganic chemistry 112, 104907, https://doi.org/10.1016/j.bioorg.2021.104907
7. Yoo, H.C.*, Yu, Y.C.*, Sung, Y.*, Han, J.M. (2020). Glutamine reliance in cell metabolism. Experimental & Molecular Medicine 52, 1496-1516, https://doi.org/10.1038/s12276-020-00504-8
6. Yoo, H.C., Park, S.J., Nam, M., Kang, J., Kim, K., Yeo, J.H., Kim, J., Heo, Y., Lee, H.S., Lee, M.Y, Lee, C.W., Kang, J.S., Kim, Y., Lee, J., Choi, J., Hwang, G., Bang S., Han, J.M. (2020). A variant of SLC1A5 is a mitochondrial glutamine transporter for metabolic reprogramming in cancer cells. Cell Metabolism 31, 267-283, https://doi.org/10.1016/j.cmet.2019.11.020
- Featured article in Cell Metabolism, Feb 04, 2020, Volume 31 Issue 2. - Featured by an editorial : Zachary E. Stine, Chi V. Dang. Glutamine Skipping the Q into Mitochondria, Trends in Molecular Medicine (2020) https://doi.org/10.1016/j.molmed.2019.11.004 - Featured by an editorial : Research Watch. An SLC1A5 Variant Transports Glutamine to Mitochondria in Cancer Cells, Cancer Discovery (2020) https://doi.org/10.1158/2159-8290.CD-RW2020-003 - Featured by an editorial : F. Dernieh. Characterisation of a mitochondrial glutamine transporter provides a new opportunity for targeting glutamine metabolism in acute myeloid leukaemia, Blood Cells, Molecules and Diseases (2020) https://doi.org/10.1016/j.bcmd.2020.102422
5. Yoon, I., Nam, M., Kim, H.K., Moon, H.S., Kim, S., Jang, J., Song, J.A., Jeong, S.J., Kim, S.B., Cho, S., Kim, Y., Lee, J., Yang, W.S., Yoo, H.C., Kim, K., Kim, M.S., Yang, A., Cho, K., Park, H.S., Hwang, G.S., Hwang, K.Y., Han, J.M., Kim, J.H., Kim. S. (2020). Glucose-dependent control of leucine metabolism by leucyl-tRNA synthetase 1. Science. https://doi.org/10.1126/science.aau2753
4. Shin, N.N., Jeon, H., Jung, Y., Baek, S., Lee, S., Yoo, H.C., Bae, G.H., Park, K., Yang, S.H., Han, J.M., Kim, I., and Kim, Y. (2019). Fluorescent 1,4-Naphthoquinones To Visualize Diffuse and Dense-Core Amyloid Plaques in APP/PS1 Transgenic Mouse Brains. Acs Chemical Neuroscience 10, 3031-3044. https://doi.org/10.1021/acschemneuro.9b00093
3. Kim, E.Y., Lee, J.G., Lee, J.M., Kim, A., Yoo, H.C., Kim, K., Lee, M., Lee, C., Han, G., Han, J.M., and Chang, Y.S. (2019). Therapeutic effects of the novel Leucyl-tRNA synthetase inhibitor BC-LI-0186 in non-small cell lung cancer. Ther Adv Med Oncol 11. https://doi.org/10.1177/1758835919846798
2. Kim, S.N., Kwon, H.J., Im, S.W., Son, Y.H., Akindehin, S., Jung, Y.S., Lee, S.J., Rhyu, I.J., Kim, Y., Seong, J.K., Lee, J., Yoo, H.C., Granneman, J.G., and Lee, Y.H. (2017). Connexin 43 is required for the maintenance of mitochondrial integrity in brown adipose tissue. Scientific Reports 7. https://doi.org/10.1038/s41598-017-07658-y
1. Kim, J.H., Lee, C., Lee, M., Wang, H.P., Kim, K., Park, S.J., Yoon, I., Jang, J., Zhao, H.C., Kim, H.K., Kwon, N.H., Jeong, S.J., Yoo, H.C., Kim, J.H., Yang, J.S., Lee, M.Y., Lee, C.W., Yun, J., Oh, S.J., Kang, J.S., Martinis, S.A., Hwang, K.Y., Guo, M., Han, G., Han, J.M., and Kim, S. (2017). Control of leucine-dependent mTORC1 pathway through chemical intervention of leucyl-tRNA synthetase and RagD interaction. Nature Communications 8. https://doi.org/10.1038/s41467-017-00785-0 |
